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Senior Scientist, Translational Immuno-Oncology Research

Novartis

Novartis

United States
Posted 6+ months ago
Position is on-site in Cambridge, MA
#LI-Onsite

About the role:
We are seeking a highly motivated and innovative Senior Scientist I/II with demonstrated knowledge of immunology, expertise in developing/executing assays leading to biomarker discovery and validation with a track record of innovation.

This is an exciting opportunity to join the Oncology Translational Research (OTR) department at Novartis Biomedical Research in Cambridge, MA. OTR is a global laboratory-based research group, which supports the development of novel therapeutics in the Oncology Disease Area from early stages of target identification through proof-of-concept clinical trials. Key activities of our group include understanding target epidemiology and biology, therapeutic mechanisms of action, response/resistance biomarkers, indication selection and rational combination opportunities across a diversity of mechanisms of action. This position is ideal for talented, highly motivated, and results-oriented individuals wishing to combine their interest in novel areas of cancer immunology with their strong desire to bridge exploratory research to early clinical trial design.

Your Key Responsibilities:

Your responsibilities include, but are not limited to:
• Support the design and execution of immunological assays, including flow cytometry-based assays, functional assays, and single-cell profiling technologies to characterize immune cell populations and identify exploratory biomarkers.
• Perform ex vivo assays including immunology-based analysis and pharmaco-dynamic studies tailored to the therapy and target of interest, with an emphasis on flow cytometry analysis of tumor, immune cells, and other tissue samples from patients.
• Develop, troubleshoot, and optimize cutting-edge immunological assays and implementing new technologies to assess mechanisms of action and exploratory biomarkers.
• Lead efforts to characterize immune cell populations from peripheral blood and tissues by implementing, analyzing, and visualizing data from novel immunological assays.
• Support efforts to develop key translational research questions related to mechanisms of action and identification of novel biomarkers from peripheral blood and tissues.
• Document, analyze, and interpret experiments in a timely manner to advise project strategy and next steps.
• Present results within a multidisciplinary team environment.